원문정보
초록
영어
GSE inhibited cell adhesion when both cell types were pretreated with GSE, the adhesion of U937cells to IL-1β-stimulated HUVECs was completely suppressed by 57.1%, 94.2%, 100.0% and 105.7% at different concentration of 5.0, 12.5, 25.0, 50.0 x 10-5%, respectively. For inquiring anti-angiogenesis mechanism, when western blot was performed with different dose of GSE extract, signal molecules of VEGFR-2, β-catenin and PI3-K were suppressed. As the signal transduction
from VEGFR-2, β-catenin and PI3-K to NF-kB was interupted, angiogenesis could not occured causing not activated NF-kB. SNU-719(stomach cancer cell), SNU-423(liver cancer cell), HCC-1428(brast cancer cell) and SNU-1005(uterine cancer) were tranplanted into nude mouse, and then observed their change of grafts. While, the grafites treated GSE with abdominal injection for 4 week into nude mouse tranplanted 4 kinds of cancer cells were perfectly necrosed. GSE is
a useful substance for developing therapeutics of angiogenesis related diseases such as cancer, metastasis, rheumathioid arthritis and obesity.