earticle

영어

Poly-γ-glutamic acid (γ-PGA) is a natural and edible polypeptide in which glutamate is polymerized via γ-amide linkages. High-molecular mass γ-PGA have been used in the field of functional cosmetics and functional food. We studied the effect of γ-PGA on the corneal wound healing, due to the anti-inflammatory effect and water retention ability of γ-PGA. In this study, the effect of γ-PGA on corneal wound healing following alkali burn was evaluated. 30 eyes wounded by alkali burn out of 30 white rabbits were divided into 3 groups ; A group treated with 0.1 % 5,000 kDa γ-PGA for two days, B group treated with 0.1 % hyaluronic acid, C group with no treatment as a control. The area of corneal epithelial defect was examined at 12, 24, 30, 36, 42, 48 hours following corneal alkali wound for initial wound healing. In this study, we found that γ-PGA was promoted the corneal wound healing compared with control and was showed similar effect compared with hyaluronic acid. These results indicate that γ-PGA stimulate the corneal wound healing by probably anti-inflammatory effect and enhancing cell migration and cell proliferation. We suggest that γ-PGA is a promising biomaterial could be substituted for hyaluronic acid in a corneal wound healing purpose.