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논문검색

Isolation of Novel Hydroxylated Isoflavones, ODI (ortho-dihydroxyisoflavone) from Traditional Korea Soybean Paste (Doenjang) and Isoflavone's Biotransformation Study

원문정보

Changhyun Roh, Kwon-Young Choi, Bishnu Prasad Pandey, Min-Ho Cha, Su-Hyun Seo, June-Hyung Kim, Jun-Seong Park, Hye Yoon Park, Ho Sik Rho, Duck Hee Kim, Ih Seop Chang, Byung-Gee Kim

한국생물공학회 한국생물공학회 학술대회 2007 춘계학술대회 및 국제심포지움 2007.04 pp.4-4
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Recently, hydroxylated products of daidzein and genistein are a growing scientific interest for their health-related qualities. Hydroxylated products have potent antioxidant properties that contribute to their cholesterol lowering effect, cardiovascular protection, antitumor effect, and anticarcinogenic properties Doenjang (Fermented Soybean paste) is a unique Korean traditional food fermented by many useful microorganisms including fungi and bacilli. Isoflavones have biological effects due to their potential beneficial properties for human health. We have been interested in a microbial metabolite of isoflavone in highly aged Doenjang. Recently, we isolated three o-dihydroxyisoflavones (ODI), 6-hydroxydaidzein (6-OHD), 8-hydroxydaidzein (8-OHD) and
3`-hydroxydaidzein (3`-OHD), and evaluated some biological activity. ODIs show predominant effect on antioxidation activity and melanogenesis inhibition. And we studied the formation of modified isoflavones from daidzein and genistein by the genus Streptomyces. Streptomyces avermitilis MA4680 could hydroxylate at ortho-specific position and methoxylate subsequently.
The great potentiality in applications such as the production of hydroxylated isoflavones and drug metabolites or bioremediation will be motivated for researchers to find new paradigm.

저자정보

  • Changhyun Roh School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea.
  • Kwon-Young Choi School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea.
  • Bishnu Prasad Pandey School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea.
  • Min-Ho Cha School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea
  • Su-Hyun Seo School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea
  • June-Hyung Kim School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea
  • Jun-Seong Park Skin Research Institute, AMOREPACIFIC R&D Center
  • Hye Yoon Park Skin Research Institute, AMOREPACIFIC R&D Center
  • Ho Sik Rho Skin Research Institute, AMOREPACIFIC R&D Center
  • Duck Hee Kim Skin Research Institute, AMOREPACIFIC R&D Center
  • Ih Seop Chang Skin Research Institute, AMOREPACIFIC R&D Center
  • Byung-Gee Kim School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, Korea. Institute of Molecular Biology and Genetics, 105-103, Seoul, Korea.

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