원문정보
초록
영어
Pathogenic bacteria are one of the etiological agent causing infectious diseases, which is serious disease leading up to even death. In this reason, identification of pathogenic bacteria is very important in clinical diagnostics. Recently, DNA microarray-based technology is receiving much attention as a powerful tool for pathogen detection [1]. In this study, we suggest diagnostic
microarray for pathogenic bacteria, which selected based on high prevalence and/or difficulty of cultivation. The probes were designed bioinformatic analysis using the sequence of 23S ribosomal DNA (rDNA) and 16S-23S rDNA intergenic spacer region. Our diagnostic microarray showed high sensitivity and specificity. The results of this study suggest that diagnostic DNA microarray facilitates more rapid and accurate identification of clinically predominant pathogenic bacteria causing infectious diseases. [This work was supported by Medigenes Co., Ltd.]