원문정보
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영어
Angelica gigas is a common traditional medicinal plant that has been used for more than several thousand years in Korea. The commonly used Angelica roots showed pharmacological properties with their chemical compositions. The main chemical constituents of Angelica roots are ferulic acid, ligustilide, angelicide, brefeldin A, butylidenephthalide, butyphthalide, succinic acid, nicotinic acid, uracil, and adenine(2). Main constituents associated with the pharmacological activities of Angelica roots showed anticancer activity(1), inhibitor of platelet aggregation, antiasthmatic and spasmolytic activities(2). The best alternation for increasing production is elicitation. We activated all secondary metabolisms by the addition of biotic elicitors to suspended cultured cells and compared secondary metabolites between control (unelicited) cells and elicited cells. Elicitor-treated cells showed higher productivity of coumarin and
coumarin derivatives than untreated cells. Also Elicitor-treated cells produced secondary metabolites which are not shown in unelicited cell by opening other secondary metabolism. We investigated major relationship between profiles of metabolite production and expression level of phenylalanine ammonia-lyase (PAL).