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The design and fabrication of scaffolds have received much attention with regard to functional vital engineered tissues. A provisional scaffold serves as a temporal cell adhesion and proliferation substrate or platform until natural extracellular matrix (ECM), which consists of a nanoscale fibrous network of proteins and proteoglycans, is produced by inoculated cells to form matrix architecture or tissue morphology, which resembles that of a native tissue. Recently, the fabrication and design of submicronto nanoscale structural architectures, which geometrically or topologically mimic the native state of ECM, have received much attention in regenerative medical applications.
Electrospinning (ELSP) is a fiber spinning technique driven by a high-voltage electrostatic field using a polymeric solution or liquid that produces polymer fibers with diameters ranging from several micrometers down to 100 nm or less. The fibers are typically deposited in the form of a non-woven fabric onto a target metallic collector through a random deposition of a projected jet of polymer solution, the so-called instable jet. To fabricate a geometrically biomimetic scaffold composed of nanoscale fibers, electrospinning has been proven to be an effective method. Furthermore, the major advantages over conventional wet spinning methods include simplicity,
convenience, and inexpensiveness.
In this talk, the principle and method of ELSP, and also medical applications especially for artificial vascular graft will be introduced.