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Protein chip technology has shown its great potential in basic research, diagnostics and drug discovery to replace the classical assay. Protein chips, compared to DNA chips, have developed slowly because protein is complex and difficult for preparation. Recently various kinds of protein chips were practical used in. In diagnostic application, protein chips can replace
immunoassay. Due to their high throughput, they have great potential to reduce the assay time and to get much information in a time. But immunoassay protocols were different depend on the target material and diseases. Competitive ELISA, antibody capture ELISA, direct ELISA and
indirect ELISA have been used in diagnostic immunoassay. They could not be assayed in a well. Determination of various items but similar molecules to be assayed in a single protocol, such as autoimmune disease or allergy can be easily applicable area in protein chip based diagnostics. In a practical use of protein chip in diagnostic area, grouping of assays is necessary and introduced.