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초록
영어
Therapeutic antibodies can be generated from many routes. At early stage of research, as many candidate antibodies as possible should be evaluated for optimal efficacy and manufacturability. For anti-cancer treatment, very high dose of antibody therapeutics are administered. Successful antibody development must overcome the challenge of high titer cell culture, maximum yield at down stream process, long-term stability in highconcentration formulation and optimal pharmacokinetic, pharmacodynamic property and minimum immunogenecity in human. How these issues could be managed at early stage of research will be discussed.
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자료제공 : 네이버학술정보