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Research Articles

Inhibitory Effect of Ethyl Acetate Extract of White Peach Pericarp on Adipogenesis of 3T3-L1 Preadipocyte Cells

원문정보

Hong Gyu Park, Jin Moon Kim, Won-Yoon Chung, Yun-Jung Yoo, Jeong-Heon Cha, Jung Mogg Kim

한국식품과학회 Food Science and Biotechnology Volume 17 Number 6 2008.12 pp.1327-1331
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

In order to determine whether peach contains compounds to regulate adipocyte differentiation, extracts of flesh/pericarp of yellow/white peach were prepared in water, ethyl acetate (EtOAc), or n-butanol solvent and determined for effectson adipocyte differentiation in C3H10T1/2 or 3T3-L1 cells. Interestingly, none of peach extracts has statistically significantstimulatory effect on the adipocyte differentiation in C3H10T1/2. Furthermore, the presence of EtOAc extract of white peachpericarp (WPP) was found to inhibit lipid accumulation in 3T3-L1 cells both by microscopic examination of Oil Red O-stained lipid droplets and by spectrophotometric quantification of extracted stain, indicating a significant inhibitory effect onadipocyte differentiation. The inhibition of lipid accumulation was accompanied by a significant decrease in the expressionlevels of adipocyte molecular markers-peroxisome proliferator-activated receptor γ, CAAT enhancer binding protein α, andfatty acid-binding protein. Thus, this study determined that WPP EtOAc extract contains the inhibitory compound(s) onadipogenesis.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

저자정보

  • Hong Gyu Park Department of Oral Biology, BK21 Project, Oral Science Research Center, Yonsei University College of Dentistry, Seoul 120-752, Korea
  • Jin Moon Kim Department of Oral Biology, BK21 Project, Oral Science Research Center, Yonsei University College of Dentistry, Seoul 120-752, Korea
  • Jung Mogg Kim Department of Microbiology and Institute of Biomedical Science, Hanyang University College of Medicine, Seoul 133-791, Korea
  • Won-Yoon Chung Department of Oral Biology, BK21 Project, Oral Science Research Center, Yonsei University College of Dentistry, Seoul 120-752, Korea
  • Yun-Jung Yoo Department of Oral Biology, BK21 Project, Oral Science Research Center, Yonsei University College of Dentistry, Seoul 120-752, Korea
  • Jeong-Heon Cha Department of Oral Biology, BK21 Project, Oral Science Research Center, Yonsei University College of Dentistry, Seoul 120-752, Korea

참고문헌

자료제공 : 네이버학술정보
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