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Research Articles

Anti-tumor and Anti-inflammatory Activity of the Methanol Extracts from Adlay Bran

원문정보

Ming-Yi Lee, Wenchang Chiang, Shu-Hsien Tsai, Yueh-Hsiung Kuo

한국식품과학회 Food Science and Biotechnology Volume 17 Number 6 2008.12 pp.1265-1271
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Adlay bran is a waste product previously thought to have no commercial value. Its methanolic extract wasfractionated using n-hexane (ABM-Hex), ethyl acetate (ABM-EtOAc), 1-butanol (ABM-BuOH), and water (ABM-H2O). TheABM-EtOAc fraction exhibited a strongest inhibition against growth of human lung cancer cell A549 and human colorectalcarcinoma cells HT-29 and COLO 205. Inhibition of cell cycle progression at G0/G1 transition, increase of cells at the sub-G1phase, and DNA ladders were observed in cells treated with ABM-EtOAc. The ABM-BuOH fraction showed the strongestinhibition of proinflammatory cytokines tumor necrosis factor (TNF)-α and interlukin (IL)-1β in stimulated RAW 264.7macrophages. Further, ABM-EtOAc and ABM-BuOH inhibited cyclooxygenase (COX)-2 expression in A549 and HT-29carcinoma cells, while COX-1 expression was not affected. These results reveal that both ABM-EtOAc and ABM-BuOH mayaid the prevention of cancers and the applications in cancer chemotherapy.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 References

키워드

저자정보

  • Ming-Yi Lee Graduate Institute of Food Science and Technology, Center for Food and Biomolecules, College of Bioresources and Agriculture, National Taiwan University, Taipei 106, Taiwan
  • Shu-Hsien Tsai Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taipei 106, Taiwan
  • Yueh-Hsiung Kuo Department of Chemistry, National Taiwan University, Taipei 106, Taiwan
  • Wenchang Chiang Graduate Institute of Food Science and Technology, Center for Food and Biomolecules, College of Bioresources and Agriculture, National Taiwan University, Taipei 106, Taiwan

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