earticle

영어

The possible protective effects of highly zinc-containing yeast Saccharomyces cerevisiae, FF-10 strain, isolatedfrom tropical fruit rambutan on acute alcoholic liver injury in rats were evaluated. Zinc concentration in this strain was 30.6mg%. The activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transpeptidase(γ-GTP) were highly increased when alcohol was treated, relative to the normal rats. Also, a highly significant increase in theblood alcohol and acetaldehyde levels by alcohol treatment was observed. Administration of FF-10 strain markedly preventedalcohol-induced elevation of the activities of serum ALT, AST, and γ-GTP, and the levels of blood alcohol and acetaldehyde,and these reduced levels reached to that of normal rats. As compared with alcohol treated control rats, the FF-10 strainsupplementation showed highly decreased the triglyceride concentration in serum. Alcohol treatment induced the markedaccumulation of small lipid droplets, hepatocytes necrosis, and inflammation, but FF-10 strain administration attenuated toalcohol-induced accumulation of small lipid droplets and hepatocyte necrosis in the liver. Therefore, the current findingsuggests that zinc-enriched yeast FF-10 strain isolated from tropical fruit rambutan may have protective effect against alcohol-induced hepatotoxicity.