earticle

영어

Present study investigated the effects of the 70% ethanol extracts of tissue-cultured mountain ginseng (TCMG),Korean red ginseng (KRG), and Panax ginseng (PG) on agonist-induced platelet aggregation and activation in human wholeblood. The IC50 values for TCMG, KRG, and PG were 1.159, 3.695, and 4.978mg/mL for collagen-induced aggregation,0.820, 2.030, and 4.743 mg/mL for arachidonic acid-induced aggregation, and 1.070, 2.617, and 2.954mg/mL for ADP-induced aggregation, respectively. Also, this study assessed the effects of the most active extract, TCMG, on markers ofplatelet activation by determining receptor expression on platelet membranes in healthy subjects, including expression ofGPIIb/IIIa-like (PAC-1) and P-selectin (CD62), by flow cytometry. A significant decrease in PAC-1 expression (p=0.018) wasobserved in the presence of TCMG. These results show that TCMG has potent anti-platelet activity.