earticle

영어

The effect of some peptides on hepatoprotection and cecal fermentation against D-galactosamine (GalN)-treatedrats was studied. In acute hepatic injury tests, serum alanine aminotransferase (ALT), aspartate aminotranferase (AST), andlactic dehydrogenase (LDH) activities were remarkably increased after injection of GalN. However, potato and soybeanpeptides significantly decreased GalN-induced alterations of serum ALT and AST activities. Hepatic thiobarbituric acid-reactive substance (TBARS) concentration in GalN-treated groups fed potato and soybean peptides was significantly lowerthan that in GalN-treated control group. Hepatic glutathione level in the GalN-treated group fed potato peptide wassignificantly higher than that in GalN-treated control group. Furthermore, cecal Lactobacillus level in GalN-treated groups fedpotato and soybean peptides was significantly higher than that in GalN-treated control group, and cecal short-chain fatty acidconcentrations in GalN-treated group fed potato peptide were significantly higher than in GalN-treated control group. Theseresults indicate that potato peptide may improve the cecal fermentation and prevent the GalN-induced liver damage in rats.