earticle

영어

This study aimed to investigate the alterations in plasma antioxidant activity after the consumption of a single oraldose of curcumin, vitamin C, and E administered individually or in combination to (i) assess possible synergies or antagonismbetween the antioxidants and (ii) determine the optimal composition of the antioxidant mixture such that the duration of actionis prolonged to beyond that of individual antioxidants. Each antioxidant was administered to male Sprague-Dawley rats, andblood samples were drawn at different time points up to 180 min to measure the plasma total antioxidant capacity (TAC). Fiveantioxidant compositions (M1-M5) were evaluated to assess the possible synergies or antagonisms among them and todetermine the optimal composition of the antioxidant mixture. Blood samples were collected up to 360 min post-consumption.A single oral dose of individual antioxidants significantly increased the TAC values; however, the time to reach the peak TACvalue varied. Among the 5 antioxidant compositions, M2 exhibited the highest and most prolonged antioxidant effect inplasma; this was greater than the proportional sum of the effects of the individual antioxidants in the composition. This resultindicates a synergistic interaction among antioxidants in the optimal composition M2.