원문정보
The Effect of Extremely Low Frequency Electromagnetic Fields on theChromosomal Instability in Bleomycin Treated Fibroblast Cells
초록
영어
In order to determine the effect of extremely low frequency electromagnetic fields (ELF-EMF) on the frequency ofmicronuclei (MN), aneuploidy and chromosomal rearrangement induced by bleomycin (BLM) in human fibroblast cells, a 60 Hz ELF-EMF of 0.8 mT field strength was applied either alone or with BLM throughout the culture period and a micronucleus-centromere assaywas performed. Our results indicate that the frequencies of MN, aneuploidy and chromosomal rearrangement induced by BLMincreased in a dose-dependent manner. The exposure of cells to 0.8 mT ELF-EMF followed by BLM exposure for 3 hours led tosignificant increases in the frequencies of MN and aneuploidy compared to BLM treatment for 3 hours alone (p<0.05), but no significantdifference was observed between field exposed and sham exposed control cells. The obtained results suggest that low density ELF-EMF could act as an enhancer of the initiation process of BLM rather than as an initiator of mutagenic effects in human fibroblast.
목차
1. 서론
2. 재료 및 방법
3. 결과와 논의
4. 결론
참고문헌
abstract