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논문

Bleomycin이 처리된 사람 섬유아세포에서 극저주파 전자기장의 효과

원문정보

The Effect of Extremely Low Frequency Electromagnetic Fields on theChromosomal Instability in Bleomycin Treated Fibroblast Cells

조윤희, 김양지, 이중원, 김계은, 정해원

피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

In order to determine the effect of extremely low frequency electromagnetic fields (ELF-EMF) on the frequency ofmicronuclei (MN), aneuploidy and chromosomal rearrangement induced by bleomycin (BLM) in human fibroblast cells, a 60 Hz ELF-EMF of 0.8 mT field strength was applied either alone or with BLM throughout the culture period and a micronucleus-centromere assaywas performed. Our results indicate that the frequencies of MN, aneuploidy and chromosomal rearrangement induced by BLMincreased in a dose-dependent manner. The exposure of cells to 0.8 mT ELF-EMF followed by BLM exposure for 3 hours led tosignificant increases in the frequencies of MN and aneuploidy compared to BLM treatment for 3 hours alone (p<0.05), but no significantdifference was observed between field exposed and sham exposed control cells. The obtained results suggest that low density ELF-EMF could act as an enhancer of the initiation process of BLM rather than as an initiator of mutagenic effects in human fibroblast.

목차

초록
 1. 서론
 2. 재료 및 방법
 3. 결과와 논의
 4. 결론
 참고문헌
 abstract

저자정보

  • 조윤희 Yoon Hee Cho. 서울대학교 보건대학원(School of Public Health, Seoul National University)
  • 김양지 Yang Jee Kim. 서울대학교 보건대학원(School of Public Health, Seoul National University)
  • 이중원 Joong Won Lee. 서울대학교 보건대학원(School of Public Health, Seoul National University)
  • 김계은 Gye Eun Kim. 서울대학교 보건대학원(School of Public Health, Seoul National University)
  • 정해원 Hai Won Chung. 서울대학교 보건대학원(School of Public Health, Seoul National University)

참고문헌

자료제공 : 네이버학술정보

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