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논문검색

Urokinase의 적출심장의 심근허혈에 대한 보호작용과 invitro 및 exvivo항혈전작용 실험

원문정보

Protective Effect of Urokinase on Reperfusion Function in Isolated Perfused Rat Heart, and Anti-platelet Aggregation Effect Invitro and Exvivo

권광일, 신흥섭, 윤정옥, 김보신, 민지하, 이병호, 허인회

피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

Protective effect of urokinase on reperfusion were studied followed by global ischemia in the isolated perfused rat heart. Separately, anti-platelet aggregation effect of urokinase also investigated. Urokinase exhibited positive effect for the protection of rat heart function by increasing the LV dp/dt, coronary flow(CF) and the Tate pressure product(RPP), and by decreasing the LVEDP on reperfusion. Urokinase also decreased arrhythmia by $74.7\%(P<0.05) induced by global ischemia in the rat heart. In the platelet aggregation study, urokinase did not show the inhibitory effect of ADP or collagen induced platelet aggregation inviuo and exvivo.

저자정보

  • 권광일 Kwon, Kwangil. 충남대학교 약학대학(College of Pharmacy, Chung Nam National University)
  • 신흥섭 Shin, Hongseup. 충남대학교 약학대학(College of Pharmacy, Chung Nam National University)
  • 윤정옥 Yoon, Jongok. 충남대학교 약학대학(College of Pharmacy, Chung Nam National University)
  • 김보신 Kim, Boshin. 충남대학교 약학대학(College of Pharmacy, Chung Nam National University)
  • 민지하 Min, Jiha. 충남대학교 약학대학(College of Pharmacy, Chung Nam National University)
  • 이병호 Lee, Byungho. 한국화학연구소(Korea Research Institute of Chemical Technology)
  • 허인회 Huh, Inhoe. 중앙대학교 약학대학(College of Pharmacy, Jung Ang University)

참고문헌

자료제공 : 네이버학술정보

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