Anti-Helicobacter pylori, Cytotoxic, and Anti-inflammatory Activities of White Ginseng Extract


Hee-Sook Jee, Kyung-Hoon Chang, Sun-Hee Moon, Se-Ho Park, Hyun-Dong Paik

피인용수 : 0(자료제공 : 네이버학술정보)



The anti-Helicobacter pylori activity, cytotoxicity, and anti-inflammatory activity of white ginseng extract (WGE) were investigated in vitro in this study. The antimicrobial effects of WGE toward H. pylori strains 52 J99, SSI, and 51 were tested using the disk diffusion method. Among these H. pylori strains, H. pylori 52 was the most sensitive, having the largest inhibition zone (19 mm), followed by J99, SSI, and 51. The zone of inhibition due to WGE increased significantly with
increasing dosage. The cytotoxicity of WGE toward the human cancer cell lines A-549 (human lung carcinoma), HEC-1-B (human endometrial adenocarcinoma), HeLa (human uterin adenocarcinoma), and SW-156 (human kidney carcinoma) was measured using the 3-(4,5-dimethylthizol-2-yl)-2,5-diphenylate-tetrazolium bromide (MTT) assay. WGE exhibited an inhibitory effect on cell growth at 2.0 mg/mL for all tumor cell lines. An analysis of anti-inflammatory activity using the RAW 264.7 cell line showed that the inhibition of nitric oxide (NO) production increased as the WGE content increased. These results demonstrate the potential of WGE to be used as a health-promoting substance.


 Materials and Methods
  Bacterial strains
  Cell lines and culture conditions
  Nitrite assay
 Results and Discussion
  Anti-H. pylori activity
  Cytotoxic effects of WGE
  Anti-inflammatory activity of WGE


  • Hee-Sook Jee Division of Animal Life Science, Konkuk University
  • Kyung-Hoon Chang Division of Animal Life Science, Konkuk University
  • Sun-Hee Moon Division of Animal Life Science, Konkuk University
  • Se-Ho Park Dongwon Korean Ginseng Co., Ltd.,
  • Hyun-Dong Paik Division of Animal Life Science, Konkuk University


자료제공 : 네이버학술정보

    함께 이용한 논문

      ※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.

      0개의 논문이 장바구니에 담겼습니다.