earticle

영어

The antioxidative activity of Alpinia oxyphylla was investigated through measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) and inhibitory activity for linoleic acid peroxidation. Two antioxidative diarylheptanoids, yakuchinone A (1) and oxyphyllacinol (2), were isolated from the fruits of A. oxyphylla using thin layer chromatography (TLC) autographic assays. The DPPH scavenging activities of the compounds (IC50=1, 57±2.1 uM; 2, 89±3.1 uM) were lower than vitamin C(IC50=51±1.1 uM), but higher than butylated hydroxytoluene (BHT,IC50=99±2.2 uM ). Also, inhibitory activities for linoleic acid peroxidation of the compounds (IC50=1, 0.19±0.011 mM, ; 2, 2, 0.31±0.009 mM ) were higher than those of vitamin C (IC50=0.59±0.017 mM) and BHT (IC50=0.52±0.014 mM). In addition the 13C-NMR data of oxyphyllacinol (2) have been first reported in this paper.