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논문검색

Neuroprotective Effect of Scopoletin from Angelica dahurica on Oxygen and Glucose Deprivation-exposed Rat Organotypic Hippocampal Slice Culture

원문정보

Son, Dong-Wook, Lee, Pyeong-Jae, Lee, Jong-Seok, Lee, Sang-Hyun, Choi, Sang-Yoon, Lee, Jong-Won, Kim, Sun-Yeou

한국식품과학회 Food Science and Biotechnology Volume 16 Number 4 2007.08 pp.632-635
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

This study examined the neuroprotective effect of scopoletin from Angelica dahurica against oxygen and glucose deprivation-induced neurotoxicity in a rat organotypic hippocampal slice culture. Scopoletin reduced the propidium iodide (PI) uptake, which is an indication of impaired cell membrane integrity. In addition, it inhibited the loss of NeuN, which represents the viability of neuronal cells. The results suggests that scopoletin from A. dahurica protects neuronal cells from the damage caused by oxygen and glucose deprivation.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

저자정보

  • Son, Dong-Wook KT&G Central Research Institute
  • Lee, Pyeong-Jae Department of Natural Medicine Resources, Semyung University
  • Lee, Jong-Seok Department of Anesthesiology and Critical Care Medicines, School of Medicine, Johns Hopkins University
  • Lee, Sang-Hyun Department of Applied Plant Science, College of Industrial Science, Chung-Ang University
  • Choi, Sang-Yoon Korea Food Research Institute
  • Lee, Jong-Won KT&G Central Research Institute
  • Kim, Sun-Yeou Department of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung Hee University

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