earticle

영어

Recently many scientists have been researching into alcoholic liver damage or liver disease, because of alcohol consumption causing severe social (or public) problems, such as addiction by alcohol, alcohol abuse and liver disease. Alcohol consumption is known to cause severe acute liver damage resulting in hepatic fibrosis and liver cirrhosis, when chronically consumed. The mechanism by which alcohol induces its damaging effects on the liver are poorly understood. This study discusses the current definition of alcoholic liver disease and the role of the components involved in innate immune response. In particular, the effect of Kupffer cells, macrophages which are present in liver, on alcohol-induced liver diseases. This review will contribute to understanding the mechanism responsible for alcoholic liver disease and the relation between the innate immune response and the pathogenesis of alcoholic liver disease.