원문정보
초록
영어
In order to find out the Radioprotective effect of algin-oligosaccharide(AOS), this study, with a mouse of which whole frame irradiated by 3 Gy radiation once, measured caspase-3 and caspase-9 amid cell signaling connected to apoptosis in order to observe cell activation.
In Caspase-3 and Caspase-9 test for observing cell activation, both of Caspase-3 and Caspase-9 showed highly increased O.D. value in the irradiation control group, while the whole groups treated with algin-oligosaccharide before or after irradiation indicated lower O.D. value than the irradiation control group, especially showed big difference in 7 day’s treatment group of before irradiation (P<0.001). It confirmed that Caspase generation was restrained in AOS treatment group.
Consequently, this study inquired into the fact that algin-oligosaccharide with superior antioxidant activity performed radiation protection by inducing restraint of Caspase generation and confirmed that natural product with less chemical toxicity was able to be applied as radioprotector.
목차
1. INTRODUCTION
2. MATERIALS AND METHODS
2.1 Experimental Materials
2.2 Classification of Experiment Groups
2.3 Experimental Methods
2.4 Statistical Analysis
3. RESULT
3.1 Caspase-3
3.2 Caspase-9
3.3 Measurement of Radiation-Induced TNF-α
4. DISCUSSION
5. CONCLUSION
REFERENCES