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Spinal nerve root metastases are extremely rare and have only been reported as individual cases, while metastases to non-primary sites are common in malignant tumors. Metastatic breast cancer often spreads to bones, liver, lungs, and brain. Among these, the bones metastasized by cancer cells include commonly the rib, vertebra, pelvis, and long bone in arm or leg. We report here a rare case that breast cancer metastasized S1-3 nerve roots. An involving patient showed thick nerve roots at the sacral intervertebral regions, which was a strong enhancement in contrast-enhanced magnetic resonance imaging. Based on a pathological examination, primary lesions of the patient were revealed as breast cancer and additional multiple metastases were founded within the brain. The clinical process was characterized by worsening radiculopathy, especially intractable pain. Radiological appearance may be similar to neurogenic tumors of lesions in the intervertebral region, because of an enlargement of the nerve root and its marked contrast enhancement. Local tumor control and pain relief can be performed through radiation therapy, but it is only palliative treatment. Thus, a metastatic possibility of malignant neoplasm should be considered in patients with radiological sign of radiculopathy.