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Despite advancements in device and implantation techniques, complications related to intrathecal drug delivery systems are common and may also produce acute withdrawal syndromes. Catheter-related problems are one of the main causes of these complications. The authors present a case of repeated loss of effectiveness of an intrathecal morphine pump following successful implantation in a patient with chronic pancreatitis. The patients experienced pain relief after implantation, but after 3 months, he complained of a sudden worsening of pain. We checked pump-catheter system based on the protocol. Lumbar spine radiographs were obtained to confirm the correct placement of both the pump and the catheter. Pump malfunction was excluded by activating the bolus mode to rotate the pump’s roller. The entire length of the catheter from the pump to the tip was then examined under fluoroscopy and a myelogram was obtained. There was no evidence of a fracture or kink, nor was there leakage at the catheter’s lumen or tip. The patient’s pain was well controlled for a short period, but the patient suffered episodes of repeated aggravation. Despite retraction of the catheter by a few centimeters, his pain recurred. A surgical exploration of the pump-catheter system was then scheduled based on our suspicion that the catheter was partially clogged. The catheter showed no apparent defects or leakage. After the replacement, the patient’s pain decreased substantially. When intrathecal drug delivery systems failure is suspected and all troubleshooting steps have failed to identify the defect, replacing the catheter system may be the final option.