원문정보
초록
영어
Phthalates could be unintentionally added into plastic materials-containing cosmetics or raw materials during manufacture and storage. Hence, the maximum permissible detection limit to phthalates has been regulated by the sum of dibutylphthalate (DBP), butylbenzylphthalate (BBP) and diethylhexylphthalate (DEHP) of 100 ppm in Korea. From the monitoring, it is found that relatively high level of phthalates was detected in eye make-up products, rinse-off products and perfumes among the 160 kinds of cosmetics. The risk assessment was carried out with two scenarios; one for harsh conditions, assuming the 97.5 percentile concentration level of phthalates to expose, and one for mild conditions, assuming the averaged concentration level of phthalates to expose. The margin of safety (MOS) of DBP, BBP and DEHP were 11742, 129482 and 14320 when 97.5 percentile concentration level was applied, respectively. Also, the aggregated risk assessment was carried out and the result was 6145 of MOS, assuming that three phthalates were exposed simultaneously. All MOS values from the assessments were larger than 100, which is not considered to be of concern to the human health.
목차
I. Introduction
II. Materials and Methods
1. Samples
2. Content of phthalates in cosmetic products by GC-MS
3. Instruments and conditions of gas chromatography-mass spectrometry (GC-MS)
4. Estimation of daily exposure level to phthalates
5. P oint o f departure ( POD) f or phthalates
6. Risk characterization
III. Results
1. Content of phthalates in cosmetic products
2. Assessment of exposure to phthalates from the cosmetic products
3. Point of departure for phthalates
4. Risk characterization
IV. Discussion
Acknowledgements
Conflicts of Interest
References