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Purpose : This study aimed to identify the effects of ethical nursing competency and social intelligence on attitudes toward organ donation after brain death among intensive care unit (ICU) nurses working in university hospitals. Method : A survey was conducted with 168 nurses who had worked for over six months in the ICUs of university hospitals with 500+ beds in City D. The data were collected from July 5 to August 15, 2022, and analyzed using descriptive statistics, t-tests, ANOVA, Pearson’s correlation coefficients, multiple regression, and the PROCESS macro with SPSS/WIN 26.0. Result : Attitudes toward organ donation after brain death were significantly correlated with social intelligence (r=.160, 𝑝=.039). Factors influencing these attitudes included hope for organ donation (β=.511, 𝑝<.001), job position (β=.251, 𝑝<.001), and social intelligence (β=.143, 𝑝=.026). These variables explained 32.7% of the variance in attitudes toward organ donation after brain death. Conclusion : This study demonstrates that social intelligence is an important factor influencing ICU nurses’ attitudes toward organ donation after brain death. Based on these findings, developing and implementing educational programs designed to enhance social intelligence may positively affect nurses’ attitudes toward organ donation after brain death and ultimately help promote organ donation from brain-dead patients.