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Purpose : This study aimed to explore hospital caregivers’ experiences of caring for patients with infections and their educational needs for infection control. Methods : This qualitative descriptive study utilized focus group interviews. Participants were 10 caregivers who had experience caring for patients with infections at a general hospital. The data were collected through four focus group interviews conducted from September 16 to 29, 2025, and analyzed using Elo and Kyngäs’s inductive content analysis method. Results : Seven categories and 30 subcategories emerged from the analysis: ‘diverse experiences of caring for patients with infections’, ‘psychological experiences related to caring for infected patients’, ‘patient characteristics and work environment causing caregiving difficult’, ‘absence of infection control support systems’, ‘educational content in need’, ‘preferred educational methods’, and ‘caregivers’ self-initiated coping and demands for improved working conditions’. Participants experienced fear and anxiety while caring for patients with tuberculosis, multidrug-resistant organisms, and scabies, yet they relied on verbal instructions from nurses or advice from fellow caregivers without systematic infection control education. Participants expressed needs for practice-oriented education including prior information on provision of infection, precautions by infection type, and donning/doffing of personal protective equipment. They preferred educational methods such as on-site information sheets, hands-on training, bedside small-group education, short modular videos, and repeated training. Conclusion : Despite performing tasks involving close contact with infected patients, caregivers were excluded from infection control education and support systems. Infection control education for caregivers should be designed considering learners’ characteristics, including age and educational background, as well as their 24-hour working environment, enabling immediate application in the field and behavioral internalization through repetition.