earticle

영어

Sorbus commixta is a deciduous tree of the Rosaceae family native to Asia. It has long been used to treat diverse diseases like asthma and neuralgia. It has been reported that extract of the bark has effective results in suppressing the production of nitric oxide (NO) and pre-inflammation by down-regulating the NF- кB pathway in lipopolysaccharide (LPS)- induced RAW 264.7 cells. Vitiligo is a chronic depigmentation disorder of the skin resulting in the selective viability of melanocytes and yet its cause has not been fully elucidated. In the present study, ethanol extract of S. commixta twigs (STE) activated melanocytes, significantly increasing the proliferation and melanin contents of B16F10 melanocytes. Because of the importance of tumor necrosis factor (TNF)-α in inflammatory diseases, including vitiligo, the antiinflammatory effects of STE were tested in TNF-α stimulated dermal fibroblasts and keratinocytes and STE reduced the mRNA and protein levels of IL-6, IL-8, and TNF-α. To evaluate the molecular mechanism of STE the protein levels of mitogen-activated protein kinase (MAPK) were determined. STE inactivated extracellular signal-regulated kinase (ERK), but not c-Jun N-terminal kinases (JNK) and p38 mitogenactivated protein kinase (p38). In addition, STE showed anti-oxidative properties on assays of DPPH radical scavenging activity. Taken together, these findings suggest that STE may have potential therapeutic activity in vitiligo.