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Purpose: This study aimed to identify the effects of health-promoting behaviors, college student burnout, and loneliness on the learning flow of senior nursing students. Methods: A descriptive study design was adopted, and the data were collected through an online survey from 136 3rd-and-4th-year nursing students in three universities. The data were analyzed using independent t-test, one-way ANOVA, Pearson’s correlation coefficient, and multiple regression analysis with SPSS 21.0 program. Results: Learning flow significantly differed depending on the satisfaction level of their major, and was significantly correlated with health-promoting behaviors, college student burnout, and loneliness. College student burnout and health-promoting behaviors significantly predicted senior nursing students’ learning flow, accounting for 30% of the variance. Conclusion: To improve learning flow of senior nursing students, interventions should focus on preventing burnout and enhancing health-promoting behaviors. Strategies may include coordinating the timing and workload of exams, assignments, and extracurricular activities, as well as increasing awareness of the importance of physical activity and encouraging its regular practice.