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Purpose: This study aimed to examine resilience, the nursing work environment, and patient-centered communi cation among hospital nurses, and to identify factors influencing person-centered nursing practice. Methods: A cross-sectional survey was conducted with 204 nurses working at a university hospital in Gyeonggi Province, South Korea. Data were collected using a structured questionnaire and analyzed with SPSS version 27.0. Descriptive statistics, independent t-tests, one-way ANOVA, Pearson’s correlation coefficients, and multiple regression analysis were employed to assess the relationships among variables and identify predictors of person-centered nursing practice. Results: Patient-centered communication (β=.54, p<.001), resilience (β=.28, p<.001), and the nursing work environment (β=.11, p=.046). significantly influenced person-centered nursing practice. Together, these factors accounted for 62% of the variance in person-centered nursing practice (F=56.44, p<.001). Conclusion: The findings highlight the importance of enhancing patient-centered communication skills, strengthening resilience, and improving the nursing work environment to promote person-centered nursing practice in hospitals. Organizational strategies and educational interventions should be systematically developed and implemented to support nurses in practicing high-quality person-centered nursing.