earticle

영어

The female infertility condition can be induced by various factors. Not only due to the cellular senescence of reproductive system, but also reproductive disorders can suppress the ovary activity. Unfortunately, many female reproductive disorders do not have effective treatment options or not effective to the underlying cause of this condition. To overcome those limitations in current treatment options, many researchers trying to find novel treatment strategies using stem cells. Mesenchymal stem cells are promising source based on their regenerative potential. In this study, we summarized recent published studies and introduce many experimental and pre-clinical data showing the therapeutic effect of stem cells in female reproductive disorder such as primary ovarian insufficiency(POI), polycystic ovary syndrome(PCOS), endometriosis. In addition, we also present the potential of stem cells for anti-ovarian aging treatment through published literature. We also introduce specialized cell culture conditions to generate improved stem cells, which have enhanced therapeutic potential for future clinical applications. Through this review study, we suggest stem cell-based therapy as a novel and fundamental treatment option for various female reproductive disorders to restore fertility in patients.