earticle

영어

Changes in DNA methylation patterns in human genes can not only impair gene activation but also contributes to epigenetic age. To measure these changes machine learning models are used which measures the degree of changes in DNA methylation pattern. Parkinson's disease is the second most common neurodegenerative disease which affects motor function. Even though it may develop before the age of 50 due to genetic factors, the gene that causes Parkinson's disease is linked to aging, so the incidence increases with age, and most people get affected by Parkinson’s disease are over the age of 50. It is a geriatric disease that occurs in older aged people. Changes in DNA methylation patterns have been observed in patients with Parkinson's disease. Therefore, the epigenetic age of patients with Parkinson's disease was measured using Epi clock, which is one of the epigenetic clock models which was trained using 6761 CpG probes from pan tissue. Additionally, the acceleration of age was measured and changes in DNA methylation patterns were confirmed. Through this, it was confirmed that although the epigenetic age of Parkinson's disease patients accelerates, the difference is small which is approximately 1 to 5 years. Even though Hypo methylation of CpG probes increased, it was to a small extent.