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Purpose: This study aimed to evaluate the shear bond strength between ceramic materials and metal substructures fabricated through casting, milling, and three-dimensional (3D) printing techniques. Methods: In total, 45 specimens were fabricated using casting, milling, and 3D-printing (N=15 per group), followed by the application of ceramic to the metal substructures; the specimen dimensions followed ISO/CD 9693 guidelines (height=10 mm, radius=6 mm). Shear bond strength was measured using a universal testing machine, with the maximum load recorded at complete fracture. Fracture patterns were examined under a scanning electron microscope (TESCAN MIRA KH-7700, Hirox). Differences in the specimens’ bond shear strength among the three fabrication techniques were assessed using one-way ANOVA, with post-hoc analysis performed using Tukey’s HSD test (α=0.05). Results: Shear bond strength differed significantly among the three fabrication methods (p<0.001). The milling group exhibited significantly higher shear bond strength than the casting and 3D-printing groups (p<0.05). Conclusion: Metal substructures fabricated via milling showed superior bond strength; therefore, milling is recommended when high shear bond strength is a clinical priority