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The purpose of this study was to investigate the effects satisfaction with major and self-induced learning ability on nursing professionalism of nursing students. Data were collected through a questionnaire of 167 students in the nursing department of A and J city Collected data were analyzed by descriptive statistics, t-test, ANOVA, Pearson's correlation coefficients and multiple regression using SPSS 29.0 program. The results showed that the satisfaction with major averaged 3.87±0.56 , the self-directed learning ability averaged 3.86±0.57, and the nursing professionalism was 3.95±0.44. Nursing professionalism was significantly different by age and satisfaction with college life. Major satisfaction (r=0.671, p<0.001) and self-directed learning ability (r=0.565, p<0.001) were significantly correlated with nursing professionalism. Satisfaction with major and self-induced learning ability were identified as influencing factors in turnover intention, and the explanatory power was 46.7%. Based on these findings, programs that develop self-directed learning ability, and satisfaction with major are necessary for nursing students to promote nursing professionalism.