earticle

영어

Electrospinning is an innovative method for producing nanofibers from biopolymers, offering a wide range of applications in the biomedical field. In this study, Gelatin-b and Cellulose Nano Crystals (CNC), modified with coumaric acid, were shown to undergo complexation under acidic conditions. This behavior was optimized using a 9:1 acetic acid to water ratio for electrospinning. Fourier-transform infrared (FT-IR) spectroscopy and confocal microscopy verified the CNC incorporation in the nanofibers, with labeled nanofibers providing insight into their structure. Scanning electron microscopy (SEM) revealed an increase in nanofiber diameter proportional to the amount of Cm-CNC added, and mechanical testing confirmed enhanced strength with greater CNC content. Furthermore, the release of payload from the nanofibers increased with higher pH levels, with a significantly higher release observed in the presence of sulfatase compared to controls without the enzyme. UV-induced dimerization of the nanofibers enabled controlled release due to photo-crosslinking.