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Objectives: This study aimed to understand the impact of nursing students’ satisfaction with clinical practice and their sense of calling on nursing professionalism. Methods: The study participants were fourth-year students in nursing departments located in G City, and a total of 268 responses to structured questionnaires were used in the final analysis. Descriptive statistics, correlation analyses, and multiple regression analyses were performed using SPSS version 26.9. Results: Satisfaction with clinical practice (r=.03, p<.001), sense of calling (r=.24 p<.00,1), and nursing professionalism (r=.17, p<.001) were significantly positively correlated. The regression analysis results showed that Satisfaction with clinical practice (β=.342, p<.001) and sense of calling (β=.213, p<.001) were influenced nursing professionalism, with and explanatory power of 26.3%. Conclusions: To improve professionalism among nursing students, it is necessary to develop and implement a clinical nursing practice intervention program that recognizes the satisfaction with clinical practice and sense of calling.