earticle

영어

This study was aimed to investigate the dietary supplementation with the fruiting body of Lyophyllum decastes (LD) mushroom on body weight, plasma lipid profiles and histopathological changes of the liver in rats fed a high-fat and high-cholesterol diet. Five-week-old female Sprague-Dawley albino rats were divided into four groups, each consisting of eight: a normal control diet (NC group), an high-fat and hhigh-cholesterol diet (HFC group), an HFC diet supplemented with 0.03% simvastatin (HFC+SS group) and an HFC diet supplemented with 5% fruiting body powder of Lyophyllum decastes (HFC+LD group). In the HFC+LD group, plasma total cholesterol (TC), low density lipoprotein (LDL-C), and triglyceride (TG) concentrations were significantly lower than those in the HFC group. Additionally, body weight gain in the HFC+LD group was lower compared to the HFC group. No adverse effects were observed in the levels of plasma albumin, creatinine, blood urea nitrogen, uric acid, glucose, and total protein in the HFC+LD group. Enzyme activities related to liver function, such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT), were similar to those in other groups including NC, HFC, HFC+SS and HFC+LD. Feeding the rats with HFC diet supplemented with mushroom powder (HFC+LD group) increased the excretion of total lipid and total cholesterol compared to HFC group in the feces. Histopathological analysis revealed that the HFC group developed hepatic steatosis, while the HFC+DL group showed only minimal fat droplets in the liver tissues. In conclusion, the results suggested that an HFC diet supplemented with 5% fruiting body powder of LD provides health benefits to rats by acting on lowering atherogenic lipid profiles and body weights.