earticle

영어

Using the design of experiments (DOE), factors affecting the droplet size of ethyl cellulose (EC) nanoparticles in the manufacturing process were analyzed to optimize process conditions. The concentration of EC dissolved in solvent (acetone or ethanol), the mixing ratio of the EC solution to distilled water, and sonication power were selected as the main variables affecting the droplet size of the nanoparticles. The effect of these variables on droplet size was examined through the signal-to-noise (S/N) ratios of the Taguchi method and ANOVA analysis. Sonication power in the acetone solvent and EC solution concentration in the ethanol solvent were identified as the most influential factors on nanoparticle size.