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Background: Neck pain is recognized as one of the common and important musculoskeletal disorders in modern society. There are many studies proving that manual therapy is one of the effective treatment methods for treating neck pain. This study compared the treatment effects of the Mulligan technique and the McKenzie technique which are widely used in clinical practice to treat neck pain, through changes in neck pain and range of motion. Methods: Forty-five sub-acute patients with mechanical neck pain were randomly divided into groups as Mulligan technique group (n=22) and McKenzie technique group (n=23). The two groups were treated 8 times for 4 weeks. The participants in both groups received home exercise program. Pain (Visual Analog Scale) and range of motion were measured before and after the treatment program. Results: In both group, the pain intensity and range of motion in all direction improved significantly (p<.001). The Mulligan technique was superior to the McKenzie technique in neck extension, lateral flexion, and rotation (p<.01), but there was no difference in neck flexion and pain intensity. Conclusion: Both the Mulligan technique and McKenzie technique were effective on neck pain and ROM in patients with mechanical neck pain. The Mulligan technique is more useful than the McKenzie technique to improve neck extension, lateral flexion, and rotation.