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This experiment studied the effect of arginine intake on blood pressure and blood variables during weight training in 20 men in their 20s. The re-sistance exercise program was performed 3 times a week at 60% of one repetition maximum for 8 weeks. The arginine intake group con-sumed 1,000 mg of arginine 2 tablets per day before weight training for 8 weeks. The placebo group was instructed to consume two of placebo with water, the same as the arginine intake group. After 8 weeks, the day after the end of the resistance exercise program, systolic pressure, diastolic pressure, total cholesterol, triglyceride, high-density lipopro-tein, low-density lipoprotein, muscle mass, and maximum muscle strength were measured. In changes in systolic blood pressure, the ar-ginine intake group was 118.20±2.40 mmHg, showed a statistically sig-nificant decrease compared to the placebo group. Triglyceride in the arginine intake group was 112.62±2.40 mg/dL, showing a statistically significant decrease compared to the placebo group. Based on these results, arginine intake during resistance exercise is judged to have a positive effect on lowering blood pressure, and is also believed to re-duce triglycerides, a blood lipid variable, so it is thought to function as a supplement during exercise.