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Novel regenerative strategies for brain rehabilitation

목차

Multipotent stem cells derived from the adult central nervous system
Neurodevelopmental process in the dentate gyrus of the adult hippocampus
Chemotherapy-induced cognitive impairment
Chemotherapy accelerates neurodegeneration, resulting in cognitive impairment
Overview of our chemobrain projects
Cisplatin-treated mice show delayed learning ability and memory dysfunction
Cisplatin penetrates the blood-brain barrier and persists long after cessation of cisplatin administration
Dysregulation of adult neurogenesis is a common cellular mechanism driving chemobrain
Adult neural stem cells/progenitors are particularly vulnerable to chemo/radiation therapy
Cisplatin suppresses Nad+ levels in the adult hippocampus
The beneficial impact of exercise on cisplatin-induced weight loss and sleep disturbance
The neuroprotective impace of exercise on cisplatin-induced cognitive impairments
NMN(Nicotinamide mononucleotide;  NAD+ precursor) is a potential therapy for chemobrain 
NMN prevents cisplatin-induced impairments in neurogenic process in adult mouse hippocampus
Cisplatin suppresses expression of Nampt and NAD+-dependent Sirt2 in the adult mouse hippocampus
Targeting Nampt-mediated NAD+ metabolic pathway in chemobrain
Thank you for your attention!

저자정보

  • Mi Hyeon Jang Department of Neurosurgery, Robert Wood Johnson Medical School Rutgers. The State University of New Jersey

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