원문정보
초록
영어
Cellulose nanocrystal (CNC) hydrogel structure aggregated with donepezil hydrochloride (DPZ) and pH control was designed for long-acting drug delivery. By introducing cationic DPZ molecule into the CNC dispersion, the electrostatic repulsion force was reduced and viscoelasticity was modulated. Adjustment of pH value to 7.7 (in cCNC/DPZ gel) by the addition of NaOH to CNC/DPZ gel further increased viscoelastic properties. The cCNC/DPZ gel also showed single syringe injection and shear-thinning behavior. Moreover, the sustained release profile of DPZ from cCNC/DPZ gel was demonstrated. In the pharmacokinetic study in rats, the subcutaneous injection of cCNC/DPZ gel provided lower maximum DPZ concentration, longer half-life, and higher mean residence time values compared to those of DPZ solution and CNC/DPZ groups. These results support that the designed cCNC/DPZ gel can be safely used for sustained delivery of DPZ following its subcutaneous injection.