원문정보
초록
영어
Oxidation sensitive microparticles were obtained through the cross-linking of TEMPO-modified cellulose nanofiber (TM CNF) and cysteamine (CA) by spray drying. On the photos of SEM micrographs, they showed that microparticles (MPs) were flat wrinkled balls-like and the size was less than 10 μm, and with the increase of CA content, the MPs became more aggregated. The signals of TM CNF which were found by the EDS spectrum appeared along with the signals of CA in MPs. In FTIR spectrum, MPs contained both TM CNF and CA peaks, and after the treatment of H2O2, the thiol groups of CA were oxidized according to the appearance of S-S signal. The melting point of the MPs which contained CA was below the melting point of free CA could be concluded by DSC analysis. The size of MPs determined by laser diffraction method was 12.1 to 13.8, it was larger than the size observed on the SEM micrographs. H2O2 effectively promoted the release of FITC-dextran from MPs, which was due to the molecular reorientation of CA after oxidation.