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Cellulose nanocrystal-containing cubic phase for controlled release of an electrically charged payload

초록

영어

Cellulose nanocrystal-containing cubic phase was produced by a melt hydration method to take a role as a drug carrier to control the release of allura red AC (a negatively charged dye). Cellulose nanocrystal was incorporated in the monoolein (MO) cubic phase without demolishing the structure of cubic phase. Through TEM microscopy, black and white lines were found on photos as water channels and MO bilayers. The phase transition temperature of the cubic phase was changed from about 72 to 70 ℃ when the cellulose nanocrystal content rose from 0 to 3 % (w/w). X-ray photon spectroscopy manifested that the cellulose nanocrystal was involved in the cubic phase. The release of the electrical charged dye within the cubic phase could be regulated via the CNC content. The more the cellulose nanocrystal contents were, the more the release degree of payload were.

저자정보

  • Hyun-Ji Kim Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea
  • Seok-Ho Park Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea
  • Seung-Hwan Lee Division of Forest Materials Science & Engineering, College of Forest and Environmental Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea
  • Jin-Chul Kim Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea

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