원문정보
초록
영어
Over-expression of reactive oxygen species (ROS) in the tissues lead to diabetic complications such as cardiac dysfunction, diabetic nephropathy and endothelial dysfunction. Pharmaceutical agents are required for the treatment and prevent of these complications. Quercetin is a polyphenol flavonoid, which is widely found in vegetables, grains and fruits, and is known for its antioxidant activity against oxidative stress. In this study, we determined that quercetin protected H9c2 cells against oxidative stress. To induce ROS in the cell, H9c2 cells were exposed to hydrogen peroxide (H2O2), hyperglycemia and sodium arsenite (NaAsO2). These materials were decreased the cell viability of H9c2 cells by oxidative stress induced time and concentration dependent. Quercetin strongly protected H9c2 cells under the stressful conditions by reducing intracellular ROS level and inhibiting apoptosis pathway. Quercetin may be useful therapeutic component for the treatment or prevention of myocardial infarction.