earticle

영어

In the emerging tissue engineering applications, porous scaffolds are used to support bone tissue cells to replace and complement the current approach of organ transplantation. The cornerstone of successful tissue engineering applications depends on two essential elements of cells and scaffolds, and the suitable design of a platform for three-dimensional (3D) scaffolding is determining both biomaterials and manufacturing protocols via detailed and exact mechanical and biological needs like biocompatibility, porosity, biodegradability, surface characteristics, and so forth. Recent carbon-nanomaterials have emerged as promising candidates for producing scaffolds that can replace tissues more efficiently. Importantly, carbon-nanomaterials (CNMs) offer interesting properties for biological applications due to their very high aspect ratio, combined with outstanding mechanical and electrical properties. In addition, the advantages of carbon nanomaterials on stem cells (such as efficient attachment, proliferation and differentiation) have been demonstrated in vivo and have provided initial consequence to support subsequent studies. In this work, a new three-dimensional (3D) printing system based on for fused deposition modeling (FDM) is developed for the fabrication of 3D nanocomposite-based microstructures. The results of our study suggest improved mechanical and biological properties of the 3D platform, and provide a high potential for application of nanomaterial scaffolds in a wide range of tissues.