원문정보
초록
영어
H2O2-triggerable liposomes were prepared by modifying the liposome surface with an H2O2-responsive polymer. DOPE liposomes can be formed by incorporating amphiphilic polymer. The polymer was synthesized by a free radical reaction. Polymerization was confirmed by 1H-NMR, and FT-IR. The degree of surface activity of the polymers was also examined. As a result of the polymer characterization, the polymer was measured amphiphilic. Liposomes were prepared by varying the content of the polymer. The quenching degree of the liposome was confirmed to be about 46.2% to 57.7%. Liposome morphology was observed with a TEM microscope. As the weight ratio of polymer to DOPE lipid increased, the average diameter of liposome increased and triggerable release of calcein. When H2O2 concentration was 0%, 1.5%, 3.0%, and 6.0%, the DOPE to polymer ratio of 200:1 liposome release about 0.5%, 50.8%, 78.0%, and 78.4%, respectively. DOPE liposome with polymer 200:4 was more susceptible to H2O2 and showed 80% release within 20 seconds.