earticle

영어

Based on the results of analysis on the antioxidant effects of glutathione, there have been studies on its diverse effects on human body. Some studies have also examined its functions such as liver function improvement & detoxification, immunity enhancement, NK cell & T-cell generation, anti-virus effects and anticancer effects. Recently, in addition to the pharmacological effects of glutathione, its effects on human skin have been investigated. While there have been studies on its effectiveness on human skin and its brightening effects through cell experiments and dietary treatments, it has been difficult to find a study on clinical trials after the use of glutathione-containing cosmetics. Therefore, this study attempted to investigate the effects of glutathione on skin pigmentation through clinical trials. For this, a double-blind test was performed against a total of 24 testees (12 persons each for experimental and control groups). Three different glutathione-free cosmetics and 3 different cosmetics containing 3% glutathione were applied to the control and experimental groups respectively twice a day in the morning and in the evening over 6 weeks. Then, skin conditions before and after the use of the cosmetics such as pores, wrinkles, skin coarseness, UV pigmentation, flushing and brightness were examined. The control group revealed no statistically significant change in pores, wrinkles, skin coarseness, UV pigmentation, flushing, brightness and skin moisture. In contrast, decrease in UV pigmentation and increase in skin bright were found in the experimental group with statistical significance even though no statistically significant changes were observed in pores, wrinkles, skin coarseness, flushing and skin moisture. Therefore, it is reasonable to conclude that glutathione is valuable as a whitening cosmetic ingredient which can enhance skin tone by reducing the skin pigmentation index.

중국어

据调查，目前多数研究基于谷胱甘肽抗氧化作用，对其多种人体功效开展了调研，谷胱甘肽有利于改善肝功能和解毒、增加免疫力、具有NK细胞和T细胞生成效果、在抗病毒、抗癌等方面均有功效。除了谷胱甘肽的药理作用，其对皮肤效果的研究也层出不穷，研究发现，针对谷胱甘肽的皮肤有效性评价，诸多研究通过细胞实验和饮食实验法对皮肤美白效果进行了调查，然而，将谷胱甘肽成分应用于人体皮肤的化妆品临床实验研究却微乎其微。因此，本研究通过化妆品临床试验，研究了谷胱甘肽成分对皮肤色素沉淀的效果。化妆品临床试验选取了24名研究对象，对照组12名，实验组12名，并采用双盲法进行实验。对照组使用了3种未添加谷胱甘肽的化妆品，实验组则使用3种添加谷胱甘肽的化妆品，每天早晚各使用2次，连续使用6周，然后分析了不同人群使用不同化妆品前后的毛孔、皱纹、皮肤粗糙度、UV色素沉淀、泛红、皮肤亮度、水分的皮肤状态变化。分析发现，对照组的毛孔、皱纹、皮肤粗糙度、UV色素沉淀、泛红、皮肤亮度、水分无明显变化；实验组的毛孔指数、皱纹指数、皮肤粗糙度、红润度、水分未呈现出统计学上的显著变化，但UV色素沉淀指数降低，皮肤亮度指数增加，具有统计学上的显著变化。因此，可推断，谷胱甘肽化妆品成分可减少皮肤色素沉淀指数，有助于提亮肤色，具有作为美白化妆品原料的应用价值。