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Purpose : To effectively manage depression among office workers, it is essential to identify and address the factors influencing depression. In this regard, the study aimed to identify the factors influencing depression among office workers aged between 30and under 65 years. Methods : The data from the 9th Korea National Health and Nutrition Examination Survey (2022) were utilized, targeting 663 office workers aged between 30 and under 65 years. D-->The data analysis was conducted using complex sample logistic regression. Results : The level of depression was 1.98 times higher in females than in males, and 2.21 times higher in unmarried individuals compared to married ones. Household income showed 0.30 times lower likelihood of depression in the 'low to middle' category compared to the 'high' group. In terms of subjective health perception, individuals reporting 'average' health were 1.94 times more likely to experience depression compared to those reporting 'good' health, while those reporting 'poor' health were 8.45 times more likely. Perceived stress was 6.04 times higher among those perceiving 'high' stress compared to 'low' stress. Depression was 1.82 times higher among those working 41-52 hours per week compared to 35-40 hours, and 2.35 times higher among those working 53 hours or more. Conclusion : To prevent depression among office workers, efforts should focus on promoting the ability to recognize and manage stress through stress management programs, as well as improvements in institutional practices such as reducing long working hours.