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Purpose : This study attempted to verify the effectiveness of a self-management program based on autogenic training to reduce job stress among research workers. Methods : The study was designed to compare the effects on psychological and physiological stress responses by applying a self-management program based on Autogenic Training for a total of 8 weeks, consisting of 4 weeks of face-to-face training and 4 weeks of non-face-to-face support program on research workers. This is a quasi-experimental study using an equivalence control group before and after the design. The subjects of the study were 49 research workers who volunteered at a research institute and were at high risk of job stress; 24 in the experimental and 25 in the control group. Results : As a result of applying a self-management program based on Autogenic training on research workers, positive effects were seen in sympathetic nerve activity, high coherence, and insomnia in the experimental group after 4 weeks of experimental intervention, and subjective stress after 8 weeks of experimental intervention. Positive changes were seen in reactivity, trait anxiety, state anxiety, high coherence, salivary cortisol, and insomnia. Conclusion : It is believed that a self-management program based on autogenic training can be applied as an efficient nursing intervention method to relieve the stress of research workers with high job stress, which ultimately improves cardiovascular disease, anxiety, and sleep patterns caused by stress. It is thought to contribute to improving the quality of life.