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Objectives: This study assessed the relationship between patient safety attitude, communication skills, nursing professionalism, and patient safety management activities. Further, it sought to identify factors affecting patient safety management activities. Methods: The study involved 174 nursing students. Data were collected through structured questionnaires from April 10 to May 1, 2023. Results: Patient safety management activity was positively correlated with patient safety attitude (r=.386, p<.001), communication skills (r=.358, p<.001), and nursing professionalism (r=.430, p<.001). Nursing professionalism (β=.271, p=.001) and patient safety attitude(β=.238, p=.001) affected patient safety management activity. These factors explained 24.9% of the variance in clinical competency. Conclusions: Cultivating nursing professionalism and fostering a positive patient safety attitude is vital for enhancing nursing students’ patient safety management activities. This can be achieved through systematic education using policy strategies involving diverse patient safety cases.